Papers

Papers published by GEM

  1. Taylor NJ, Reiner AS, Begg CB, Cust AE, Busam KJ, Anton-Culver H, Dwyer T, From L, Gallagher RP, Gruber SB, Rosso S, White KA, Zanetti R, Orlow I, Thomas NE, Rebbeck TR, Berwick M, Kanetsky PA; on behalf of the GEM Study Group. Inherited variation at MC1R and ASIP and association with melanoma-specific survival. Int J Cancer. 2014 Nov 10. doi: 10.1002/ijc.29317. [Epub ahead of print] PMID: 25382380
  2. Thomas NE, Kricker A, Waxweiler WT, Dillon PM, Busam KJ, From L, Groben PA, Armstrong BK, Anton-Culver H, Gruber SB, Marrett LD, Gallagher RP, Zanetti R, Rosso S, Dwyer T, Venn A, Kanetsky PA, Orlow I, Paine S, Ollila DW, Reiner AS, Luo L, Hao H, Frank JS, Begg CB, Berwick M, for the GEM Study Group. Comparison of Clinicopathologic Features and Survival of Histopathologically Amelanotic and Pigmented Melanomas: A Population-Based Study. JAMA Dermatology. NIHMSID #596134
  3. Berwick M, Reiner AS, Paine S, Armstrong BK, Kricker A, Goumas C, Cust AE, Thomas NE, Groben PA, From L, Busam K, Orlow I, Marrett LD, Gallagher RP, Gruber SB, Anton-Culver H, Rosso S. Zanetti R, Kanetsky PA, Dwyer T, Venn A, Lee-Taylor J, Begg CB for the GEM Study Group. Sun Exposure and Melanoma Survival: A GEM Study. [Cancer Epidemiol Biomarkers and Prev, 2014. Epub ahead of print]. PMID: 25069694. NIHMSID#617203 (PMC in progress)
  4. Berwick M, Macarthur J, Orlow I, Kanetsky P, Begg CB, Luo L, Reiner A, Sharma A, Armstrong BK, Kricker A, Cust AE, Marrett LD, Gruber SB, Anton-Culver H, Zanetti R, Rosso S, Gallagher RP, Dwyer T, Venn A, Busam K, From L, White K, Thomas NE; The GEM Study Group. MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors. Pigment Cell Melanoma Res. 2014 ; 27:485-8.PMID: 25506078. PMCID: PMC3988207.
  5. Vuong K, McGeechan K, Armstrong BK; AMFS Investigators; GEM Investigators; Cust AE. Occupational sun exposure and risk of melanoma according to anatomical site. Int J Cancer 2014. PMID: 24288300. PMCID: PMC39960350.
  6. Thomas NE, Busam KJ, From L, Kricker A, Bruce K, BK, Anton-Culver H, Gruber SB, Gallagher RP, Zanetti R, Rosso S, Dwyer T, Venn A, Kanetsky PA, Groben PA, Hao H, Orlow I, Reiner AS, Luo L, Paine S, Ollila DW, Wilcox H, Begg CB, Berwick M, and The GEM Study Group. Tumor infiltrating lymphocyte grade in primary melanoma: relationship to pathologic fures and melanoma-specific survival in the population-based GEM study. J Clin Oncol. 2013 Nov 20;31(33):4252-9. doi: 10.1200/JCO.2013.51.3002. Epub 2013 Oct 14. PMCID: PMC3821014.
  7. Kricker A, Armstrong BK, Goumas C, Thomas NE, From L, Busam K, Kanetsky PA, Gallagher RP, Marrett LD, Groben PA, Gruber SB, Anton-Culver H, Rosso S, Dwyer T, Berwick M. Survival for patients with single and multiple primary melanomas in the GEM study. JAMA Dermatol 2013; 149:921-7. PMID: 23784017.
  8. Hay J, Ostroff J, Martin A, Serle N, Soma S, Mujumdar U, Berwick M. Skin cancer risk discussions in melanoma-affected families. J Cancer Educ 2005; 20(4):240-6. PMID 16497137
  9. Raimondi S, Gandini S, Fargnoli MC, Bagnardi V, Maisonneuve P, Specchia C, Kumar R, Nagore E, Han J, Hansson J, Kanetsky PA, Ghiorzo P, Gruis NA, Dwyer T, Blizzard L, Fernandez-de-Misa R, Branicki W, Debniak T, Morling N, Landi MT, Palmieri G, Ribas G, Stratigos A, Cornelius L, Motokawa T, Anno S, Helsing P, Wong TH, Autier P, Garcia-Borron JC, Little J, Newton-Bishop J, Sera F, Liu F, Kayser M, Nijsten T; Gem Study Group; M-SKIP Study Group. Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiologic studies. BMC Med Res methodol. 2012; 116. PMID 22862891. PMCID: PMC3502117.
  10. Mukherjee B, Delancey JO, Raskin L, Everett J, Jeter J, Begg CB, Orlow I, Berwick M, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Culver HA, Rosso S, Zanetti R, Kanetsky PA, From L, Gruber SB; GEM Study Investigators. Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers. J Natl Cancer Inst. 2012;104(12):953-6. Epub 2012 Apr 24. PMID: 22534780. PMCID: PMC3379723.
  11. Murali R, Goumas C, Kricker A, From L, Busam KJ, Begg CB, Dwyer T, Gruber SB, Kanetsky PA, Orlow I, Rosso S, Thomas NE, Berwick M, Scolyer RA, Armstrong BK; GEM Study Group. Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas. Ann Surg Oncol. 2012;19:1024-33. Epub 2011.PMID: 21913010. PMCID: PMC3288299.
  12. Berwick M, Begg CB, Armstrong BK, Reiner AS, Thomas NE, Cook LS, Orlow I, Kricker A, Marrett LD, Gruber SB, Anton-Culber H, Millikan RC, Gallagher RP, Dwyer T, Rosso S, Kanetsky PA, Lee-Taylor J. Interaction of CDKN2A and sun exposure in the etiology of melanoma in the general population. J Invest Dermatol 2011; Epub ahead of print. PMID 21857749. PMCID: PMC3213249.
  13. Mandelcorn-Monson R, Marrett L, Kricker A, Armstrong BK, Orlow I. Goumas C, Paine S. Rosso S, Thomas N, Millikan RC, Pole JD, Cotignola J, Rosen C, Kanetsky PA, Lee-Taylor J, Begg CB, Berwick M. Sun exposure, vitamin D receptor polymorphisms FokI and BsmI and risk of multiple primary melanoma. Cancer Epidemiol. 2011; 35:e105-10. PMID 21612999. PMCID: PMC3182291,
  14. Conway K, Edmiston SN, Khondker ZS, Groben PA, Zhou X, Chu H, Kuan PF, Hao H, Carson C, Berwick M, Olilla DW, Thomas NE. DNA-methylation profiling distinguishes malignant melanomas from benign nevi. Pigment Cell Melanoma Res. 2011;24(2):352-360. PMID:21375697 PMCID: PMC3073305
  15. Orlow I, Roy P, Reiner AS, Yoo S, Patel H, Paine S, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Thomas NE, Gruber SB, Anton-Culver H, Rosso S, Gallagher RP, Dwyer T, Kanetsky PA, Busam K, From L, Begg CB, Berwick M; for the GEM Study Group. Vitamin D receptor polymorphisms in patients with cutaneous melanoma. Int J Cancer. 2012 PMID: 21365644. PMCID: PMC3135781.
  16. Thomas NE, Kricker A, From L, Busam KJ, Millikan RC, Ritchey ME, Armstrong BK, Lee-Taylor J, Marrett L, Anton-Culver H, Zanetti R, Rosso S, Gallagher RP, Dwyer T, Goumas C, Kanetsky PA, Begg CB, Orlow I, Wilcox H, Paine S, Berwick M. Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis. Cancer Epidemiol Biomarkers Prev. 2010 ; 19:2932-41. PMID: 20802019. PMCID: PMC2976811.
  17. Kricker A, Armstrong BK, Goumas C, Kanetsky P, Gallagher RP, Begg CB, Millikan RC, Dwyer T, Rosso S, Marrett LD, Thomas NE, Berwick M; GEM Study Group. MC1R genotype may modify the effect of sun exposure on melanoma risk in the GEM study. Cancer Causes Control. 2010 21:2137-47. PMID: 20721616. PMCID: PMC3010306.
  18. Thomas NE, Kanetsky PA, Edmiston SN, Alexander A, Begg CB, Groben PA, Hao H, Busam K, Ollila DW, Berwick M, Conway K. Relationship between Germline MC1R Variants and BRAF-Mutant Melanoma in a North Carolina Population-Based Study. J Invest Dermatol. 2010 May;130(5):1463-5. PMID: 20043015. PMCID: PMC2950750.
  19. Thomas NE, Kanetsky PA, Begg CB, Conway K, Berwick M. Melanoma molecular subtypes: unifying and paradoxical results. J Invest Dermatol. 2010 Jan;130(1):12-4. PMID: 20010862. PMCID: PMC2950747
  20. Orlow I, Tommasi DV, Bloom B, Ostrovnaya I, Cotignola J, Mujumdar U, Busam KJ, Jungbluth AA, Scolyer RA, Thompson JF, Armstrong BK, Berwick M, Thomas NE, Begg CB. Evaluation of the Clonal Origin of Multiple Primary Melanomas Using Molecular Profiling. J Invest Dermatol. 2009; 129(8):1972-82. PMID: 19282844. PMCID: PMC2745834.
  21. Mujumdar UJ, Hay JL, Monroe-Hinds YC, Hummer AJ, Begg CB, Wilcox HB, Oliveria SA, Berwick M. Sun protection and skin self-examination in melanoma survivors. Psychooncology. Oct 2009; 18(10):1106-15. PMID: 19142859. PMCID: PMC2756464
  22. Hay J, Shuk E, Brady MS, Berwick M, Ostroff J, Halpern A. Family communication after melanoma diagnosis. Arch Dermatol. 2008 Apr;144(4):553-4.PMID: 18427057, PMCID: PMC3619973.
  23. Capanu M, Orlow I, Berwick M, Hummer AJ, Thomas DC, Begg CB. The use of hierarchical models for estimating relative risks of individual genetic variants: An application to a study of melanoma. Stat Med. 2008; 27(11):1973-92. PMID: 18335566. PMCID: PMC2722963.
  24. Stitzenberg KB, Thomas NE, Dalton K, Brier SE, Ollila DW, Berwick M, Mattingly D, Millikan RC. Distance to diagnosing provider as a measure of access for patients with melanoma. Arch Dermatol. 2007;143(8):991-8. PMID 17709657. PMCID: PMC3629703.
  25. Thomas NE, Edmiston SN, Alexander A, Millikan RC, Groben PA, Hao H, Tolbert D, Berwick M, Busam K, Begg CB, Mattingly D, Ollila DW, Tse CK, Hummer A, Lee-Taylor J, Conway K. Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanomas. Cancer Epidemiol Biomarkers Prev 2007;16(5). PMID 17507627
  26. Orlow I, Begg CB, Cotignola J, Roy P, Hummer AJ, Clas BA, Mujumdat U, Canchola R, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Kanetsky PA, Wilcox H, Busam K, From L, Berwick M. CDKN2A Germline Mutations in Individuals with Cutaneous Malignant Melanoma. J Invest Dermatol. 2007: 127:1234-43. PMID 17218939
  27. Kricker A, Armstrong BK, Goumas C, Litchfield M, Begg CB, Hummer AJ, Marrett LD, Theis B, Millikan RC, Thomas N, Culver HA, Gallagher RP, Dwyer T, Rebbeck TR, Kanetsky PA, Busam K, From L, Mujumdar U, Zanetti R, Berwick M; for the GEM Study Group. Ambient UV, personal sun exposure and risk of multiple primary melanomas. Cancer Causes Control. 2007 Apr;18(3):295-304. PMID 17206532
  28. Kanetsky PA, Rebbeck TR, Hummer AJ, Panossian S, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Culver HA, Zanetti R, Gallagher RP, Dwyer T, Busam K, From L, Mujumdar U, Wilcox H, Begg CB, Berwick M. and the GEM Study Group. Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma. Cancer Res 2006;66:9330-7. PMID 16982779
  29. Berwick M, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Kanetsky PA, Busam K, From L, Mujumdar U, Wilcox H, Begg CB and The GEM Study Group. The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: An international population-based study. Cancer Epidemiol Biomarkers Prev 2006;15(8):1-6. PMID 16896043
  30. Thomas NE, Berwick M, Cordeiro Stone M. Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation? J Invest Dermatol; 2006;126(8):1693-6. PMID 16845408
  31. Begg CB, Hummer AJ, Mujumdar U, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Culver HA, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Busam K, From L. Berwick M for the GEM Study Team. A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma. Int J Epidemiol. 2006, 35(3):756-64. PMID 16556646
  32. Millikan RC, Hummer A, Begg C, Player J, de Cotret AR, Winkel S, Mohrenweiser H, Thomas N, Arstrong B, Kricker A, Marrett LD, Gruber SB, Anton-Culber H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck T, Busam K, From L, Mujumdar U, Berwick M. Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma study. Carcinogenesis. 2006; 27(3):610-618. PMID 16258177
  33. Begg CB, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Mitra N, Busam K, From L, Berwick M: Genes Environment and Melanoma Study Group. Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample. J Natl Cancer Inst. 2005;97(20):1507-15. PMID 16234564
  34. Begg CB, Hummer A, Mujumdar U, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Klotz JB, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Berwick M. Familial aggregation of melanoma risks in a large population-based sample of melanoma. Cancer Causes Control. 2004 Nov;15(9):957-65. PMID 15577298
  35. Thomas NE, Alexander A, Edmiston SE, Parrish E, Millikan RC, Berwick M, Groben P, Ollila DW, Conway K. Tandem BRAF mutations in primary invasive melanomas. Journal of Investigative Dermatology 2004, 122(5):1245-50. PMID 15140228
  36. Amend KL, Elder JT, Tomsho LP, Bonner JD, Johnson TM, Schwartz J, Berwick M, Gruber SB. EGF gene polymorphism and the risk of incident primary melanoma. Cancer Research 2004, 64:2668-72 PMID 15087376
  37. **Berwick M, Orlow I, Mahabir S, Myskowski P, Coit D, Brady MS, Roy P, Song YS, Canchola R, Barz A, Halpern A, Bolognia J, Eng S, Elahi A, Begg CBB. Estimating the relative risk of developing melanoma in INK4A carriers. European J Cancer Prevention, 2004 13 (1):65-70. PMID 15075790
  38. **Orlow I, Roy P, Barz A, Canchola R, Song Y, Begg CB, Berwick M. Validation of a rapid detection method-denaturing high performance liquid chromatography (DHPLC) for the identification of human INK4A gene mutations. J Mol Diag 2001; 3:158-163. PMID 11687599
  39. *Begg C, Berwick M. A note on the estimation of relative risks of rare genetic susceptibility markers. Cancer Epidemiology Biomarkers and Prevention 1997;6:99-103. PMID 9037560: *Explains the premise of the comparison between multiple primary melanoma and single primary melanoma: to more efficiently evaluate more rare genetic variants in the general population.

**Pilot studies that demonstrate the validity of the design